From Softening Fine Lines to Smoothing Texture, These Are Our Favorite Anti-Aging Serums for Mature Skin (2024)

This retinol-packed serum helps to visibly minimize lines and wrinkles in the skin, in addition to boosting firmness and radiance. What makes this retinol serum unique is its fast-acting Retinol Tri-Active technology, which is a time-released retinol and vitamin A booster that helps minimize any potential irritation that retinol can sometimes cause.

Don’t sleep on drugstore antiaging serums—you don’t always have to shell out $100+ to get a high-quality serum. This Neutrogena serum (not recommended for retinol newbies) contains the brand’s highest concentration of 0.5 percent pure retinol, combined with nourishing emollients that work to target signs of aging like fine lines, wrinkles, and dark spots.

We love a travel-friendly skincare product that also keeps the product potent longer. This retinol serum comes in capsule form to ensure peak efficacy and precise dosing, so you’re never wasting product. The serum is supercharged with firming ceramides and line-softening retinol to address multiple signs of premature aging.

This exfoliating serum works overnight to rejuvenate skin by sloughing away dead skin and impurities without over-drying. The youth-boosting formula is infused with mandelic acid and niacinamide, which helps accelerate cell turnover without irritation. This is a great serum for those who can’t tolerate retinoids or simply want a gentler formula that actually works.

A multi-benefit milky serum, this lactic acid and vitamin C serum works to brighten, hydrate, plump, and gently exfoliate the skin while also targeting fine lines, wrinkles, and dark spots. The affordable glow-boosting serum also contains niacinamide and upcycled white pine that combat uneven tone and texture.

This clean, superfruit-packed vitamin C serum is rich in antioxidants, helping to reduce the signs of photoaging: fine lines, enlarged pores, dullness, and hyperpigmentation. REN specifically formulated this serum to limit irritation, using a combination of three types of vitamin C, along with glycogen and hyaluronic acid, making it a good option for those with sensitive skin.